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Patents/USRE049351

USRE049351No. USRE049351reissueGranted 1/3/2023

Claims (16)

Claim 1 (Independent)

1. A method of treatment of cerebral hemorrhagic infarction, comprising the step of administering a drug containing a triprenyl phenol of formula (II) or formula (III) to a patient affected by cerebral hemorrhagic infarction:

Claim 5 (Independent)

5. A method for treating cerebral thrombosis in a human subject in need thereof, comprising administering a therapeutically effective amount of a compound represented by formula (III) to the human subject suffering from cerebral thrombosis, wherein use of a thrombolytic drug is contraindicated in the human subject:

Claim 6 (Independent)

6. A method for treating cerebral embolism in a human subject in need thereof, comprising administering: to a subject experiencing a cerebral embolism and having experienced at least one symptom of said cerebral embolism for three or more hours, a therapeutically effective amount of a compound represented by formula (III) to the human subject:

Claim 7 (Independent)

7. A method for treating cerebral embolism in a human subject in need thereof, comprising administering: to a subject experiencing a cerebral embolism and having a contraindication for use of a thrombolytic drug, a therapeutically effective amount of a triprenyl phenol of formula (III) to the human subject:

Claim 8 (Independent)

8. A method of reducing ischemia reperfusion damage in a human subject, wherein the human subject is suffering from cerebral thrombosis or cerebral embolism and having experienced at least one symptom of said cerebral thrombosis or cerebral embolism for three or more hours, said method comprising administering a therapeutically effective amount of a triprenyl phenol of formula (III) to the human subject:

Claim 9 (Independent)

9. A method for treating cerebral thrombosis in a human subject in need thereof, comprising administering, to the subject suffering from cerebral thrombosis and having experienced at least one symptom of said cerebral thrombosis for three or more hours, a therapeutically effective amount of a triprenyl phenol of formula (III) to the human subject:

Claim 10 (Independent)

10. The method of claim 9, wherein said administering is carried out within 12 hours of onset of at least one symptom of cerebral thrombosis.

Claim 11 (Independent)

11. The method of claim 9, wherein said subject has discontinued thrombolytic drug treatment for cerebral thrombosis.

Claim 12 (Independent)

12. The method of claim 9, wherein said administering is carried out after the administration of a thrombolytic drug.

Claim 13 (Independent)

13. The method of claim 9, wherein no additional thrombolytic drug is administered to the subject in combination with the compound of formula (III).

Claim 14 (Independent)

14. The method of claim 7, wherein said triprenyl phenol of formula (III) has Y and Z jointly forming a bond and n is 3.

Claim 15 (Independent)

15. The method of claim 8, wherein said triprenyl phenol of formula (III) has Y and Z jointly forming a bond and n is 3.

Claim 16 (Independent)

16. The method of claim 9, wherein said triprenyl phenol of formula (III) has Y and Z jointly forming a bond and n is 3.

Show 3 dependent claims
Claim 2 (depends on 1)

2. The method of treatment of cerebral hemorrhagic infarction according to claim 1 , wherein the triprenyl phenol compound is SMTP-7.

Claim 3 (depends on 1)

3. The method of treatment of cerebral hemorrhagic infarction according to claim 1 , wherein the patient is a patient with respect to whom treatment with a thrombolytic drug is contraindicated.

Claim 4 (depends on 3)

4. The method of treatment of cerebral hemorrhagic infarction according to claim 3 , wherein the triprenyl phenol compound is SMTP-7.

Full Description

No description text available for this patent.

Citations

This patent cites (18)

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